Here, PA Sport looks at 10 of the most momentous occasions in the stadium's proud history.
19 February 1910. After previously residing at North Road and Bank Street, United, who used to be known as Newton Heath, took up residence at Old Trafford, a new 80,000 capacity stadium constructed at a cost of £60,000. The opening game ended in a 4-3 defeat to Liverpool.
25 March 1939. Surprisingly, Old Trafford's biggest attendance was not for a game involving Manchester United. The landmark was achieved in an FA Cup semi-final between Wolves and Grimsby. The figure? 76,962.
11 March 1941. Having survived one bombing raid, Old Trafford once more came under attack from the Luftwaffe. The damage was so extensive it was 1949 before the stadium could be reopened for football, forcing United to seek temporary shelter with City at Maine Road.
4 April 1953. The arrival of arguably United's greatest player. Even Sir Bobby Charlton admits Duncan Edwards was the best. As a 16-year-old, Edwards made his bow in a 4-1 defeat to Cardiff. The sadness was he perished along with so many others in Munich less than five years later.
21 March 1984. Ask fans to pick out an Old Trafford memory and there are plenty to choose from. But was any better than this? Against a Barcelona team containing Diego Maradona at his peak, United were 2-0 down from the first leg but roared back, with Bryan Robson carried off shoulder high for an astounding performance in a three-goal triumph.
3 May 1993. Old Trafford had waited 26 years to acclaim the champions. The first Premier League title had been won the previous day. This was a time to party. A sensational atmosphere for a hungover United's 3-1 win over Blackburn.
9 October 1993. So famous for football, Old Trafford was the venue for one of the most memorable fights in British boxing history when Chris Eubank and Nigel Benn battled each other to a standstill - and a draw in their WBC/WBO super-middleweight unification fight.
6 October 2001. When Wembley was closed for rebuilding, England played at a number of grounds, including Old Trafford. There was drama aplenty too when the Three Lions took on Greece and required an injury-time David Beckham free-kick to seal a place at the 2002 World Cup.
28 September 2004. There have been many debuts at Old Trafford. But probably none was as dramatic as the way Wayne Rooney announced himself to the Red Devils faithful, firing home an unbelievable hat-trick against Fenerbahce.
6 February 2008. There have been many poignant days too. But probably none as moving as the day red and blue came together to honour the 50th anniversary of the Munich air crash. Given how well behaved their supporters were, perhaps it was fitting Manchester City won the derby 2-1.